![]() Honey Kansara *, Riddhi Panola, Dr. Free download software for epson printer. Amul Mishra Bhupal Nobal’s Institute of Pharmaceutical Sciences, Udaipur, India Corresponding Author: Honey Kansara E-mail: [email protected] Date of Submission: Date of Acceptance: Conflict of Interest: NIL Source of Support: NONE Copyright: © 2015 Honey Kansara et al, publisher and licensee IYPF. ![]() This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. Cara mendownload buku gratis. Related article at. Traditionally, nearly 40% of the new chemical entities (NCEs) identified by pharmaceutical industry screening programs have failed to be developed because of poor water-solubility, which makes their formulation difficult or even impossible. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various traditional and novel techniques that that can be used for solubility enhancement of BCS Class II drugs are briefly discussed in this article. The Traditional techniques that has been discussed in this article includes use of co-solvents, Hydrotropy, Micronization, change in dielectric constant of solvent, amorphous forms, chemical modification of drug, use of surfactants, inclusion complex, alteration of pH of solvent, use of hydrates or solvates, use of soluble prodrugs, application of ultrasonic waves, functional polymer technology, controlled precipitation technology, evaporative precipitation in aqueous solution, use of precipitation inhibitors, solvent deposition, precipitation, selective adsorption on insoluble carriers. Bcs Class 1 DrugsNovel drug delivery technologies developed in recent years for solubility enhancement of insoluble drugs are size reduction technologies, lipid based delivery system, micellar technologies, porous micro particle technology. Solid Dispersion Technique and various types of solid dispersion systems have also been explained briefly. Interested in Oral Drug Delivery? Visit our upcoming 'In Vivo Predictive Dissolution Conference' page to learn more about GI physiology and BCS subclasses, human in vivo results and hydrodynamics, product and regulatory concerns, and other topics. FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. Bcs Class 4The Biopharmaceutical Classification System (BCS) has been a prognostic tool for assessing the potential effects of formulation on the human drug oral bioavailability. When used in conjunction with in vitro dissolution tests, the BCS can support the prediction of in vivo product performance and the development of mechanistic models that support formulation assessments through the generation of “what if” scenarios. To date, the applicability of existing human BCS criteria has not been evaluated in dogs, thereby limiting its use in canine drug development. Therefore, we examined 50 drugs for which absolute bioavailability ( F) was available both in dogs and humans. The drugs were also evaluated for any potential association between solubility (calculated from the dose number, Do) or lipophilicity (LogP) and F in dogs.
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